Eplerenone in patients with systolic heart failure and mild symptoms Topic: Aldosterone antagonists in heart failure with reduced ejection fraction Aim: To investigate the effects of eplerenone, added to evidence based therapy, on clinical outcomes in patients with systolic heart failure and mild symptoms (NYHA class II) Design: Multicenter, randomized,

Bisoprolol or enalapril followed by their combination for patients with congestive heart failure (CHF) and left ventricular ejection fraction (LVEF) ≤ 35% Topic: Beta-blockers in heart failure with reduced ejection fraction Aim: To assess the optimum order of initiating CHF therapy using enalapril or bisoprolol for 6 months followed by

Nebivolol in heart failure patients ≥ 70 years of age, regardless of ejection fraction Topic: Beta-blockers in heart failure with reduced ejection fraction Aim: To assess outcomes of nebivolol in HF patients >70 years of age, regardless of ejection fraction Design: Parallel group, randomized, double-blind, multi-center international trial Treatment: Nebivolol

Carvedilol versus placebo for patients with severe congestive heart failure and left ventricular ejection fraction (LVEF) < 25% Topic: Beta-blockers in heart failure with reduced ejection fraction Aim: To assess the effect of beta-blockers in patients with severe heart failure Design: Large-scale, prospective, randomized, double-blind, placebo-controlled trial of carvedilol on

Bisoprolol versus placebo for patients with congestive heart failure III/IV and left ventricular ejection fraction ≤ 35% Topic: Beta-blockers in heart failure with reduced ejection fraction Aim: Beta blockade with bisoprolol may decrease all-cause mortality in patients with chronic heart failure. Design: Multi-centered, double blinded, randomized control trial Treatment: Initial